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3 Publications visible to you, out of a total of 3
Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans.

Abstract (Expand)

While control of Mycobacterium tuberculosis (Mtb) infection is generally understood to require Th1 cells and IFNgamma, infection produces a spectrum of immunological and pathological phenotypes in … diverse human populations. By characterizing Mtb infection in mouse strains that model the genetic heterogeneity of an outbred population, we identified strains that control Mtb comparably to a standard IFNgamma-dependent mouse model but with substantially lower lung IFNgamma levels. We report that these mice have a significantly altered CD4 T cell profile that specifically lacks the terminal effector Th1 subset and that this phenotype is detectable before infection. These mice still require T cells to control bacterial burden but are less dependent on IFNgamma signaling. Instead, noncanonical immune features such as Th17-like CD4 and gammadeltaT cells correlate with low bacterial burden. We find the same Th17 transcriptional programs are associated with resistance to Mtb infection in humans, implicating specific non-Th1 T cell responses as a common feature of Mtb control across species.

Authors: M. K. Proulx, C. D. Wiggins, C. J. Reames, C. Wu, M. C. Kiritsy, P. Xu, J. C. Gallant, P. S. Grace, B. A. Fenderson, C. M. Smith, C. S. Lindestam Arlehamn, G. Alter, D. A. Lauffenburger, C. M. Sassetti

Date Published: 7th Jul 2025

Publication Type: Journal

High-dose intravenous BCG vaccination induces enhanced immune signaling in the airways

Abstract

Not specified

Authors: Joshua M. Peters, Edward B. Irvine, Mohau S. Makatsa, Jacob M. Rosenberg, Marc H. Wadsworth, Travis K. Hughes, Matthew S. Sutton, Sarah K. Nyquist, Joshua D. Bromley, Rajib Mondal, Mario Roederer, Robert A. Seder, Patricia A. Darrah, Galit Alter, Chetan Seshadri, JoAnne L. Flynn, Alex K. Shalek, Sarah M. Fortune, Bryan D. Bryson

Date Published: 2025

Publication Type: Journal

Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity

Abstract

Not specified

Authors: Joshua M. Peters, Hannah P. Gideon, Travis K. Hughes, Cal Gunnarson, Pauline Maiello, Douaa Mugahid, Sarah K. Nyquist, Joshua D. Bromley, Paul C. Blainey, Beth F. Junecko, Molly L. Nelson, Douglas A. Lauffenburger, Philana Ling Lin, JoAnne L. Flynn, Alex K. Shalek, Sarah M. Fortune, Joshua T. Mattila, Bryan D. Bryson

Date Published: 1st May 2024

Publication Type: Journal

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